Endocrine Abstracts

Age-related cognitive decline in postmenopausal women is thought to be partially related to the loss of sex steroids. Like women, old female rhesus monkeys (Macaca mulatta) undergo menopause and show an associated decline in circulating estradiol levels. Similarly, they show an age-related decline in the release of dehydroepiandrosterone (DHEA) from their adrenal glands. Because DHEA acts as a substrate for estradiol synthesis in the brain, it is plausible that DHEA sup...